منابع مشابه
Modeling molecular mechanisms in the axon.
Axons are living systems that display highly dynamic changes in stiffness, viscosity, and internal stress. However, the mechanistic origin of these phenomenological properties remains elusive. Here we establish a computational mechanics model that interprets cellular-level characteristics as emergent properties from molecular-level events. We create an axon model of discrete microtubules, which...
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In order to form a functional nervous system, neurones extend axons, often over long distances, to reach their targets. This process is controlled by extracellular receptors and their ligands, several families of which have been identified. These proteins may act to either repel or attract growth cones and a given receptor may transduce either type of signal, depending on the cellular context. ...
متن کاملMolecular mechanisms of axon growth and guidance.
PROTEINS THAT PROMOTE NEURITE OUTGROWTH ............................................................ 119 Soh~ble Neurotrophic Agents .................................................................................... 122 ECM Proteins .......................................................................................................... 123 CAMs .................................................
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Axon degeneration is a characteristic event in many neurodegenerative conditions including stroke, glaucoma, and motor neuropathies. However, the molecular pathways that regulate this process remain unclear. Axon loss in chronic neurodegenerative diseases share many morphological features with those in acute injuries, and expression of the Wallerian degeneration slow (WldS) transgene delays ner...
متن کاملCellular and molecular mechanisms underlying axon formation, growth, and branching
Proper brain wiring during development is pivotal for adult brain function. Neurons display a high degree of polarization both morphologically and functionally, and this polarization requires the segregation of mRNA, proteins, and lipids into the axonal or somatodendritic domains. Recent discoveries have provided insight into many aspects of the cell biology of axonal development including axon...
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ژورنال
عنوان ژورنال: Computational Mechanics
سال: 2016
ISSN: 0178-7675,1432-0924
DOI: 10.1007/s00466-016-1359-y